Impaired Signaling Intrinsic to Sinoatrial Node Pacemaker Cells Affects Heart Rate Variability during Cardiac Disease
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چکیده
منابع مشابه
Impaired signaling intrinsic to sinoatrial node pacemaker cells affects heart rate variability during cardiac disease.
The normal heart beat intervals are neither strictly stationary nor completely random, and continuously shift from one period to another. Decoding the ECG identifies this "hidden" information that imparts inherent complexity to the heart-beating interval time series. Loss of this complexity in cardiovascular disease is manifested as a reduction in heart rate variability (HRV) and this reduction...
متن کاملThe fractal-like complexity of heart rate variability beyond neurotransmitters and autonomic receptors: signaling intrinsic to sinoatrial node pacemaker cells.
The heart rate and rhythm are controlled by complex chaotic neural, chemical and hormonal networks which are not strictly regular, but exhibit fluctuations across multiple time scales. A careful assessment of the heart rate variability (HRV) offers clues to this complexity. A reduction in HRV, specifically in advanced age, is associated with increase in morbidity and mortality. Mechanisms that ...
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Cardiovascular function is regulated by the rhythmicity of circadian, infradian and ultradian clocks. Specific time scales of different cell types drive their functions: circadian gene regulation at hours scale, activation-inactivation cycles of ion channels at millisecond scales, the heart's beating rate at hundreds of millisecond scales, and low frequency autonomic signaling at cycles of tens...
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The effects of intercellular coupling conductance on the activity of two electrically coupled isolated rabbit sinoatrial nodal cells were investigated. A computer-controlled version of the "coupling clamp" technique was used in which isolated sinoatrial nodal cells, not physically in contact with each other, were electrically coupled at various values of ohmic coupling conductance, mimicking th...
متن کاملFactors controlling pacemaker action in cells of the sinoatrial node.
• Studies of the effects of imposed drive on isolated mammalian sinoatrial (SA) node pacemaker cells were undertaken as a result of the observed effects of rapid drive imposed on in situ pacemakers. Such studies are not new since Gaskell in 1884 observed that tetanic stimulation of the turtle sinus venosus or atria had an inhibitory effect on pacemaker function. In the most recent studies of th...
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ژورنال
عنوان ژورنال: Journal of Clinical Trials
سال: 2014
ISSN: 2167-0870
DOI: 10.4172/2167-0870.1000152